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ITCC P4
ITCC P4
Data Resource:  ITCC P4
Point of Contact:  
German Cancer Research Center (DKFZ),  
Program

About This Dataset
Cancer remains the leading cause of disease-related death in children. For the ~25% of children who experience relapses of their malignant tumors, usually after very intensive first-line therapy, curative treatment options are scarce. Preclinical drug testing to identify promising treatment options that match the molecular make-up of the tumor is hampered by the fact that i) molecular genetic data on pediatric tumors from relapsed patients and thus our understanding of tumor evolution and therapy resistance are very limited to date and ii) for many of the high-risk entities, no appropriate and molecularly well characterized patient-derived models and/or genetic mouse models are currently available. Thus, quality-assured upfront preclinical testing of novel molecularly targeted compounds in a (saturated) repertoire of well-characterized models will establish the basis to increase therapeutic successes of these drugs in children with malignancies. Since these tumors are overall genetically much less complex than their adult counterparts, it is anticipated that it will be easier to identify powerful predictive biomarkers to allow for accurate matching of targets and drugs.
Core Data Elements
Case Disease Diagnosis
Atypical Teratoid Rhabdoid Tumor (); Clear Cell Sarcoma of the Kidney (); Embryonal Tumour with Multilayered Rosettes (); Ependymoma (); Ewing Sarcoma (); High-Grade Glioma (); High-Grade Neuroepithelial Tumour with BCOR Alteration (); Kidney Tumour (); Leukemia (); Lymphoma (); Malignant Nerve Sheath Tumour (); Medulloblastoma (); Neuroblastoma (); Osteosarcoma (); Other Sarcoma (); Retinoblastoma (); Rhabdoid Tumours (); Rhabdomyosarcoma (); Synovial Sarcoma ()
Additional Data Elements
DATA REPOSITORY
Published In
https://www.itccp4.eu/news/scientific-publications